Failure to achieve pregnancy even after three in vitro fertilization programs despite high-quality embryo transfer is considered recurrent IVF failure.
After embryo transfer, pregnancy occurs when the dialogue between the embryo and the intrauterine membrane is healthy. Otherwise, it means that there is a problem with the embryo or the uterus. If we examine the reasons for the failures under two headings:
Causes of the embryo;
- Genetic problems of the embryo,
- The embryo’s metabolism is slow, its energy is insufficient, and accordingly, it cannot continue to divide and cannot adhere to the uterus,
- In advanced ages, embryos over 35 years of age have old cytoplasm and the embryo’s outer membrane is thick.
Causes related to the uterus are;
- Insufficient thickening of the intrauterine membrane,
- Intrauterine immune system being more active than normal and destroying the embryo by accepting it as foreign,
- Absence of vascularization that will allow the embryo to settle in the uterus,
- Coagulation in the thin veins that affect the embryo’s attachment and growth in the uterus,
- Undetectable fluid accumulation in the tubes,
- Presence of congenital structural defect in the uterus and Endometriosis (chocolate cyst) disease.
In recurrent IVF failures, the genetic or systemic diseases of the mother and father-to-be should be correctly diagnosed. In this context, appropriate treatment methods should be applied by performing chromosome analysis, genetic coagulation factors and immunological tests.
